Critical Care Research
Advancing Care, Recovery & Outcomes in Children Experiencing Critical Illness
ÎÚÑ»ÊÓƵ Children’s brings lab science, engineering, and clinical research together to improve survival and recovery during critical illness. We design advanced life support technologies and develop precision tools that guide treatment in real time.
We work to help children survive and preserve organ function so they have the best chance to grow up healthy and strong.
Key Areas of ResearchÂ
Cellular Drivers of Organ Failure | Studying how mitochondrial dysfunction and inflammatory stress disrupt organ function during critical illness and identifying targets that may restore cellular energy and stability.
Engineering Safer Life Support Systems | Designing next-generation extracorporeal life support technologies that improve oxygen exchange and reduce complications during critical illness.
Real-Time Organ Function Monitoring | Developing noninvasive tools that measure breathing and physiologic stress in real time to guide treatment decisions in intensive care settings.
Cardiac Intensive Care Outcomes & Surgical Recovery | Analyzing surgical and intensive care data to identify best practices and improve recovery after complex heart procedures.
Recovery After Critical Illness | Investigating long-term immune disruption and neurodevelopmental outcomes in children after sepsis, shock, and complex intensive care.
Critical Care Clinical Trials & Studies
Clinical research is important in advancing care for children with life-threatening illness. Our investigators lead and participate in federally funded research focused on pediatric sepsis, mitochondrial dysfunction, cardiac intensive care outcomes, and strategies that protect organs during critical illness.
We contribute to national registries and collaboratives that guide evidence-based intensive care. Our teams also advance translational studies that evaluate fluid resuscitation approaches, long-term recovery after sepsis, and next-generation life support technologies designed to improve safety and outcomes for critically ill children.
Where Critical Care Research Happens
Critical care research at ÎÚÑ»ÊÓƵ connects advanced laboratories with the clinicians who care for children in our neonatal and pediatric intensive care units in the Delaware Valley and Florida. Scientists studying organ failure in sepsis and shock work closely with teams developing life support technologies, improving heart surgery recovery, and refining respiratory monitoring tools. This close collaboration means new discoveries can quickly inform how we treat critically ill children.
Related Research
Biomedical Research, Innovation & Translation in Extracorporeal Life Support
DELAWARE VALLEY
We combine bioengineering, medicine, and chemistry to develop safer, more effective life support technologies for children with severe cardiorespiratory failure.
Cardiovascular Services Department Research, Florida
FLORIDA
Our researchers use imaging, data analysis, and molecular research to develop new approaches to prevent, diagnose, and treat congenital and acquired heart conditions in children.
Center for Pediatric Lung Research
DELAWARE VALLEY
Our center improves pediatric respiratory care by translating scientific discoveries into innovative diagnostics, specialized lab research, and cross-specialty clinical studies.
Critical Care Mitochondrial Unit
DELAWARE VALLEY
Investigators in our lab study how mitochondrial function affects critically ill children to improve recovery and guide personalized treatments.
ÎÚÑ»ÊÓƵ Cardiac Center for Research & Innovation
DELAWARE VALLEY
We study the impact of innovations, access, and health care delivery on outcomes in heart surgery, preventive cardiology, and more.
Noninvasive Pulmonary Evaluation Lab
DELAWARE VALLEY
Our team develops and tests noninvasive tools to assess lung function in children, aiming to improve diagnosis, monitoring, and care for respiratory conditions.
Critical Clinical Care
Cardiac Center, Delaware Valley
CLINICAL CARE
Pediatric cardiology, heart surgery, and transplantation at ÎÚÑ»ÊÓƵ Children’s Hospital, Delaware and throughout Greater Philadelphia.
Cardiac Center, Florida
CLINICAL CARE
Pediatric cardiology and specialty care at ÎÚÑ»ÊÓƵ Children’s Hospital, Florida and throughout Northeast, Northwest, and Central Florida.
Extracorporeal Membrane Oxygenation (ECMO)
CLINICAL CARE
Advanced life support technology that stabilizes critically ill children in intensive care units in Delaware and Florida when their heart or lungs cannot function on their own.
Neonatology
CLINICAL CARE
Expert intensive care for premature and critically ill newborns at advanced facilities at ÎÚÑ»ÊÓƵ Children’s hospitals in Delaware and Florida.
Pediatric Critical Care
CLINICAL CARE
Critical care for children with serious illness or injury in specialized units at our Delaware and Florida children's hospitals.
Pulmonology
CLINICAL CARE
Comprehensive care for children with lung, airway, and breathing disorders provided by ÎÚÑ»ÊÓƵ pediatric pulmonologists.